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Long-Term Protocol Safety

Meaning

Long-Term Protocol Safety is the clinical and regulatory commitment to evaluating and mitigating potential adverse health outcomes associated with a specific therapeutic regimen over an extended period, often years or decades. In hormonal health, this is particularly relevant for hormone replacement therapies, or HRT, and other longevity protocols where treatment duration is indefinite. The primary focus is on balancing the immediate clinical benefits against the cumulative risks to cardiovascular, skeletal, and oncological health. Ensuring safety requires continuous monitoring and dose titration based on evolving clinical evidence and patient response.