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Long-Term Hormone Therapy Safety

Meaning

Long-term hormone therapy safety refers to the comprehensive clinical evaluation and meticulous risk-benefit assessment of using exogenous hormone replacement or modulatory therapy over an extended period, often spanning many years or decades. The clinical focus is on understanding the cumulative, integrated impact of treatment on major organ systems, including cardiovascular, skeletal, and mammary health, as well as the potential for oncogenic risk. This rigorous, ongoing assessment is critical for personalized endocrine management, particularly in postmenopausal women, transgender individuals, and those with chronic hormonal deficiencies.