Long Term Fatigue Pathophysiology refers to the complex, underlying biological and physiological mechanisms that drive persistent, debilitating fatigue not explained by conventional medical diagnoses. This pathophysiology often involves a cascade of interconnected dysfunctions, including chronic low-grade inflammation, mitochondrial impairment, HPA axis dysregulation, and neurotransmitter imbalance. Understanding this multifaceted root cause is essential for effective clinical management of chronic energy deficiency states.
Origin
This term integrates “fatigue,” the subjective symptom of profound exhaustion, with “pathophysiology,” the disordered physiological processes associated with disease or injury. It evolved from the clinical observation that chronic fatigue states often involve systemic, measurable biological changes beyond simple psychological distress. It provides a scientific framework for addressing chronic fatigue in the context of hormonal and metabolic health.
Mechanism
A key mechanism involves chronic activation of the Cellular Danger Response (CDR), leading to a persistent energy crisis at the mitochondrial level and subsequent ATP synthesis impairment. Concurrently, HPA axis dysfunction results in suboptimal cortisol signaling, which compromises the body’s ability to maintain stable energy levels and manage inflammation. This state is further compounded by chronic oxidative stress and depletion of crucial co-factors required for efficient energy metabolism and neurotransmitter synthesis.
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