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Long Term Fatigue Pathophysiology

Meaning

Long Term Fatigue Pathophysiology refers to the complex, underlying biological and physiological mechanisms that drive persistent, debilitating fatigue not explained by conventional medical diagnoses. This pathophysiology often involves a cascade of interconnected dysfunctions, including chronic low-grade inflammation, mitochondrial impairment, HPA axis dysregulation, and neurotransmitter imbalance. Understanding this multifaceted root cause is essential for effective clinical management of chronic energy deficiency states.