The sustained maintenance of higher-order executive functions, memory, processing speed, and neuroplasticity across the aging process, resisting the pathological decline associated with neurodegeneration. This state reflects robust cerebral vascularity, optimal neurotransmitter balance, and protection against chronic neuroinflammation. It is a primary objective in holistic longevity planning.
Origin
This concept bridges neurology, cognitive psychology, and endocrinology, acknowledging that systemic health, particularly hormonal balance, profoundly affects brain function over decades. Health implies functional capacity, not merely the absence of overt disease.
Mechanism
Mechanisms supporting long-term health include adequate cerebral blood flow maintained by healthy vascular endothelium, often supported by optimal sex hormone levels. Furthermore, neurotrophic factor signaling, such as BDNF, which can be modulated by exercise and metabolic state, supports synaptic plasticity. Controlling systemic inflammation is also crucial to prevent microglial activation and subsequent neuronal damage.
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