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Long-Term Clomiphene Use

Meaning

Long-term Clomiphene use refers to the clinical administration of Clomiphene Citrate (CC) extending beyond the standard, intermittent treatment cycles typically prescribed for fertility induction. In the context of male hormonal health, this often involves continuous or prolonged dosing regimens used off-label to stimulate endogenous testosterone production by blocking estrogen receptors in the hypothalamus and pituitary. This extended duration of therapy necessitates careful clinical monitoring for potential cumulative side effects, particularly those affecting visual function and lipid metabolism, which may not manifest during short-term use. The goal is to sustain elevated testosterone levels while preserving the integrity of the hypothalamic-pituitary-gonadal (HPG) axis.