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Local Hormone Therapy

Meaning

Local Hormone Therapy, specifically in the context of women’s health, involves the application of a hormone, typically a low dose of estrogen, directly to a target tissue, such as the vaginal area, to treat localized symptoms while minimizing systemic absorption. This therapeutic approach is designed to exert its primary biological effect precisely where it is needed, offering effective relief from conditions like genitourinary syndrome of menopause (GSM) without significantly increasing circulating hormone levels throughout the body. The objective is to restore the health and function of hormone-dependent tissues with the lowest possible systemic exposure. This distinction from systemic hormone therapy is a crucial consideration in clinical risk assessment.