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Lipotoxicity Reversal

Meaning

Lipotoxicity Reversal is the clinical strategy aimed at mitigating and reversing the pathological damage caused by the chronic accumulation of excess lipids, specifically non-esterified fatty acids and triglycerides, in non-adipose tissues like the liver, muscle, heart, and pancreas. This accumulation interferes with cellular signaling, induces organelle dysfunction, and contributes significantly to insulin resistance and systemic inflammation. The reversal process focuses on restoring the proper partitioning of lipids and enhancing the metabolic capacity of cells to handle fatty acids appropriately. This is a crucial intervention for improving metabolic syndrome and cardiovascular risk.