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Lipoprotein a Particle Number

Meaning

Lipoprotein a Particle Number, often denoted as Lp(a) P, quantifies the concentration of Lipoprotein(a) particles in the circulation, a distinct type of low-density lipoprotein-like particle. Lp(a) is a highly atherogenic and pro-thrombotic lipoprotein, the levels of which are largely determined by genetics and are minimally affected by traditional lifestyle modifications. Elevated Lp(a) P is a significant, independent, and causal risk factor for atherosclerotic cardiovascular disease and aortic stenosis, irrespective of standard LDL-C levels. This measurement is crucial for identifying individuals with a high, often unrecognized, residual cardiovascular risk in longevity-focused clinical practice.