Skip to main content

Lipopolysaccharide Translocation

Meaning

The pathological process where lipopolysaccharide (LPS), a potent pro-inflammatory component of the outer membrane of Gram-negative bacteria, crosses a compromised intestinal epithelial barrier and enters the systemic circulation. This translocation, often referred to as “leaky gut,” triggers a widespread, low-grade systemic inflammatory response. The presence of circulating LPS, or endotoxemia, is a major driver of metabolic dysfunction and hormonal resistance.