Lipidomic Assessment is the comprehensive, quantitative, and qualitative analysis of all lipid molecular species within a biological system, such as plasma, cells, or tissues. This advanced diagnostic tool goes far beyond standard cholesterol panels to measure the specific classes and subclasses of lipids, including ceramides, phospholipids, and oxidized fatty acids, providing a detailed snapshot of cellular membrane health, energy storage, and inflammatory status. The assessment offers a deeper, more predictive insight into metabolic and cardiovascular risk.
Origin
The term is derived from “lipidomics,” which is a sub-discipline of metabolomics, combining “lipid” (fat molecules) with the suffix “-omics,” signifying a comprehensive, systems-level study. This field emerged with the advancement of mass spectrometry and chromatography techniques, allowing for the simultaneous measurement of thousands of individual lipid species. The assessment reflects a paradigm shift towards molecular-level understanding of lipid-related pathology.
Mechanism
The mechanism involves extracting lipids from a biological sample and separating them using high-resolution chromatography before their precise identification and quantification by mass spectrometry. The resulting lipid profile reveals the subtle imbalances in lipid synthesis, degradation, and transport pathways. Clinically, this detailed molecular signature helps identify specific, actionable lipid species that drive insulin resistance, atherosclerosis, and inflammation, enabling highly targeted therapeutic interventions.
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