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Lipid Architecture

Meaning

Lipid Architecture refers to the complex, three-dimensional structural organization and composition of the lipid bilayer that forms all cellular and organelle membranes, including the critical lipid rafts where many hormone receptors reside. This architecture is not static; it is a dynamic mosaic of phospholipids, cholesterol, and other sterols whose precise arrangement dictates membrane fluidity, signaling capacity, and the proper function of embedded proteins. Maintaining optimal lipid architecture is essential for robust cellular communication and hormonal sensitivity.