The controlled exposure of an individual to specific wavelengths and intensities of visible or non-visible light for a therapeutic effect, primarily to regulate circadian rhythms, enhance mood, and modulate specific cellular processes. This non-pharmacological intervention is used to treat seasonal affective disorder, non-24-hour sleep-wake rhythm disorder, and optimize the timing of hormonal secretion. Precise timing and spectrum are critical for efficacy.
Origin
The practice of using light for health dates back to ancient times, but the modern, scientific application of light therapy developed with the understanding of the photoreceptive systems beyond vision. Its clinical foundation lies in chronobiology and the discovery of intrinsically photosensitive retinal ganglion cells (ipRGCs) that signal directly to the suprachiasmatic nucleus. It leverages environmental input to correct internal biological timing.
Mechanism
Exposure to bright, typically blue-enriched, light in the morning directly stimulates the ipRGCs, sending a strong signal to the suprachiasmatic nucleus (SCN), the body’s master clock. This signal suppresses the nocturnal production of melatonin, thereby reinforcing the desired diurnal phase of the circadian rhythm. Conversely, avoiding blue light exposure in the evening is essential to permit the natural rise of melatonin and facilitate sleep-wake cycle entrainment.
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