A Light Dosing Protocol is a clinically structured, individualized regimen that specifies the precise timing, intensity (measured in lux), and spectral quality of light exposure throughout the 24-hour cycle to optimize circadian rhythm and hormonal output. This therapeutic intervention uses light as a non-pharmacological agent to treat conditions like seasonal affective disorder, non-24-hour sleep-wake disorder, and circadian misalignment. It moves beyond general recommendations to a quantified, prescriptive approach.
Origin
The concept originates from clinical chronotherapy, applying the established principles of photoneuroendocrinology to practical patient management. The term ‘Dosing Protocol’ emphasizes the need for precision, mirroring pharmacological intervention strategies. It reflects the recognition of light as a powerful biological modulator requiring careful calibration.
Mechanism
The protocol works by leveraging the sensitivity of the intrinsically photosensitive retinal ganglion cells (ipRGCs) to specific wavelengths and intensities of light. Strategic morning light exposure induces a phase advance, while strict avoidance of short-wavelength light in the evening prevents a phase delay. This precise photonic input ensures the appropriate timing of melatonin and cortisol secretion, thereby synchronizing the entire endocrine cascade.
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