A Lifespan Strategy is a comprehensive, proactive clinical and behavioral plan designed to optimize health and function across the entire duration of an individual’s life, with the dual goals of extending chronological longevity and maximizing healthspan. This strategy integrates personalized medical interventions, nutritional protocols, physical conditioning, and hormonal balancing to mitigate age-related disease risk and maintain high quality of life into advanced age. It represents a systematic commitment to proactive, long-term well-being.
Origin
The term draws from the fields of gerontology, public health, and precision medicine, moving beyond the reactive model of disease treatment to a proactive model of health preservation. The scientific basis is the growing understanding of the biological determinants of aging, allowing for targeted interventions to slow the rate of senescence. Its philosophical origin lies in the desire to not just live longer, but to live healthier for the entire duration.
Mechanism
The strategy operates by targeting the core mechanisms of aging, including cellular senescence, mitochondrial dysfunction, and chronic low-grade inflammation, through evidence-based interventions. Hormonal optimization is a central mechanism, as the decline in key hormones, such as growth hormone, DHEA, and sex steroids, is strongly correlated with functional decline and frailty. By maintaining a youthful endocrine milieu, the strategy supports tissue repair, metabolic function, and overall systemic resilience.
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