Lifespan Science is the broad, interdisciplinary field dedicated to understanding the fundamental biological determinants that govern the duration of life and the maintenance of physiological function throughout aging. This science seeks to identify and manipulate the conserved molecular pathways that influence the rate of senescence and extend the ‘healthspan’—the period of life spent in good health. We explore mechanisms that promote cellular resilience against accumulated damage. This is the pursuit of optimized longevity.
Origin
This area of study draws heavily from gerontology, molecular biology, and evolutionary biology, seeking common themes across species regarding aging processes. The term ‘lifespan’ directly refers to the total duration of existence, while ‘science’ implies rigorous, evidence-based investigation into its underlying causality. It represents a modern expansion of research focused on extending the healthy years of life.
Mechanism
Key mechanisms investigated include the regulation of nutrient-sensing pathways, such as the mTOR and sirtuin pathways, which directly influence cellular metabolism and repair capacity. Furthermore, lifespan science examines the role of proteostasis, mitochondrial health, and the epigenetic landscape in maintaining functional integrity over time. Interventions targeting these pathways aim to slow the accumulation of molecular damage that characterizes aging.
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