What is the Origin of Lifespan Healthspan Extension?

This is a core tenet of modern longevity science and gerontology, representing a conceptual evolution from simply curing disease to actively promoting vitality across the entire life course. The distinction between lifespan and healthspan highlights the importance of functional capacity. It has become a measurable outcome in clinical trials of anti-aging interventions.

What is the Mechanism of Lifespan Healthspan Extension?

Extension is pursued by targeting the nine hallmarks of aging, including genomic instability, telomere attrition, and mitochondrial dysfunction. Protocols often involve pharmaceutical agents, caloric restriction mimetics, and hormonal optimization to enhance cellular repair mechanisms. By maintaining cellular and systemic homeostasis, the onset and progression of age-related diseases are delayed, effectively extending the period of robust health.

Lifespan Healthspan Extension

Meaning

Lifespan Healthspan Extension is the dual clinical goal of increasing the total number of years an individual lives (lifespan) and, more importantly, maximizing the proportion of those years spent in excellent health, free from chronic disease and functional decline (healthspan). The primary focus is on extending the healthspan, as this dictates the quality of life in later years. Achieving this extension involves modulating the fundamental biological processes of aging.