Specific biological pathways, pharmacological agents, or lifestyle interventions that have been scientifically validated to increase the total duration of an organism’s life. These vectors represent the targeted clinical strategies utilized in longevity medicine to slow the rate of biological aging and delay the onset of age-related diseases. They are distinct from healthspan maximization, focusing on the chronological length of life itself.
Origin
The concept originates in biogerontology, the scientific study of the biological processes of aging, drawing heavily on research into model organisms where genetic and pharmacological manipulations have successfully extended survival. The term “vector” implies a directional, targeted approach to influence the biological clock.
Mechanism
Key vectors operate by modulating fundamental cellular processes such as DNA repair, telomere maintenance, nutrient sensing pathways (e.g., AMPK, sirtuins), and the management of reactive oxygen species. Pharmacological examples include compounds that mimic the effects of caloric restriction, while lifestyle vectors center on optimizing metabolic flexibility and minimizing cellular stress, all aiming to sustain cellular function and reduce the cumulative burden of age-related damage.
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