What is the Origin of Lifespan Extension Science?

This term is rooted in gerontology, the study of aging, and its modern iteration incorporates molecular biology, genetics, and pharmacology. The concept has evolved from philosophical inquiry to a rigorous scientific discipline with the advent of model organism studies demonstrating reproducible life extension. It provides the foundational research for many clinical anti-aging and longevity protocols.

What is the Mechanism of Lifespan Extension Science?

The primary mechanisms under investigation involve modulating conserved longevity pathways, such as those related to nutrient sensing (e.g., sirtuins, mTOR, AMPK) and cellular repair processes (e.g., autophagy, DNA repair). Interventions often aim to reduce the accumulation of cellular damage, enhance mitochondrial function, and improve resistance to stress. The clinical translation focuses on pharmacological agents and lifestyle strategies that mimic the effects of beneficial genetic mutations or caloric restriction.

Lifespan Extension Science

Meaning

Lifespan Extension Science is the interdisciplinary field of study dedicated to understanding the biological processes of aging and developing interventions that increase the maximum duration of life, known as chronological lifespan. This scientific pursuit investigates genetic, molecular, and physiological mechanisms that regulate senescence and survival. While distinct from healthspan extension, its findings often overlap, focusing on fundamental biological mechanisms of longevity.