What is the Origin of Lifespan Extension Research?

This field emerged from gerontology and biogerontology, driven by the desire to understand why organisms age and how that process can be modulated. The research encompasses genetic, cellular, and systemic interventions. It has strong ties to hormonal health, as the decline of key hormones is a hallmark of the aging process.

What is the Mechanism of Lifespan Extension Research?

Interventions explored in this research often target metabolic pathways like the mTOR and AMPK signaling cascades, which regulate nutrient sensing and cellular repair. Hormonal strategies, such as the optimization of DHEA, Growth Hormone, and sex steroids, are studied for their potential to counteract age-related decline in tissue repair and metabolic function. The mechanism involves leveraging the body's endogenous repair systems and modulating gene expression to promote cellular longevity.

Lifespan Extension Research ∞ Area

Lifespan Extension Research

Meaning

Lifespan Extension Research is the scientific and clinical investigation into the biological mechanisms of aging and the development of interventions designed to increase both chronological life expectancy and healthspan. This domain focuses on understanding fundamental aging processes, such as telomere attrition, cellular senescence, and mitochondrial dysfunction. The ultimate goal is to delay the onset of age-related diseases and maintain high functional capacity well into advanced age.