Lifespan Extension Protocols encompass targeted interventions, often involving pharmacological agents or intensive lifestyle modifications, designed to mitigate age-related physiological decline and extend the period of maximal healthspan. Within the domain of hormonal health, these protocols frequently target the optimization of anabolic signaling, metabolic efficiency, and the mitigation of chronic low-grade inflammation. The objective is not merely chronological longevity but the maintenance of robust endocrine and physiological function into advanced age.
Origin
This terminology arises from the biogerontology research field, where ‘lifespan’ refers to the total duration of life, and ‘extension’ implies deliberate modification of that duration. ‘Protocols’ denotes the systematic, repeatable procedures employed to achieve this outcome. Its relevance to endocrinology stems from the understanding that age-related hormonal shifts, such as somatopause or andropause, are central drivers of senescence. We define these as structured approaches to promoting systemic resilience.
Mechanism
The mechanism often involves manipulating core longevity pathways such as mTOR, AMPK, or sirtuins, frequently through nutritional manipulation or specific pharmaceutical agents that mimic caloric restriction. Hormonal protocols may include optimizing growth hormone/IGF-1 axis signaling within safe parameters or managing thyroid hormone output to maintain basal metabolic rate. Successful protocols aim to preserve mitochondrial function and reduce cellular senescence, thereby slowing the systemic degradation that limits maximal lifespan.
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