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Lifelong Cognitive Resilience

Meaning

Lifelong cognitive resilience is the sustained capacity of the central nervous system to maintain optimal function, adapt to stress, and resist age-related decline throughout the human lifespan. This state is characterized by robust neuroplasticity, efficient neuronal communication, and minimized pathological accumulation, such as amyloid plaques or tau tangles. Hormonal balance, particularly the neurosteroids and thyroid hormones, plays a critical modulatory role in fortifying this resilience against environmental and biological stressors. It is a key metric for successful aging in longevity studies.