What is the Origin of Life Span Extension Strategy?

The concept originates from the rigorous scientific field of biogerontology, which scientifically investigates the fundamental mechanisms of aging. The strategies are based on robust findings from model organisms showing that manipulation of specific genetic or environmental factors can significantly increase longevity. The term formalizes these scientific possibilities into a practical, though often experimental, therapeutic framework for human application.

What is the Mechanism of Life Span Extension Strategy?

The primary mechanisms target the established hallmarks of aging, such as telomere attrition, mitochondrial dysfunction, cellular senescence, and deregulated nutrient sensing pathways like mTOR and AMPK. Interventions may include caloric restriction mimetics or senolytics, which act at the cellular level to maintain genomic stability and enhance cellular energy production. By modulating these core pathways, the strategy directly influences the rate of biological aging and systemic breakdown.

Life Span Extension Strategy ∞ Area

Life Span Extension Strategy

Meaning

A Life Span Extension Strategy is a deliberate, multi-faceted intervention plan aimed at increasing the total number of years an organism lives, specifically focusing on the biological and molecular processes of aging. These strategies often involve pharmacological agents, targeted nutritional protocols, and profound lifestyle modifications designed to slow the rate of cellular senescence and systemic decline. This concept is distinct from, though often overlapping with, healthspan extension, which focuses on years of good health.