What is the Origin of Life Span Extension?

This concept is foundational to the field of gerontology, derived from the historical human desire to prolong life and maintain vigor. The modern scientific pursuit of life span extension is rooted in molecular biology and genetics, emerging from studies of model organisms that demonstrate the plasticity of the aging process. The term is a central pillar of anti-aging and regenerative medicine research, driving significant investment and discovery.

What is the Mechanism of Life Span Extension?

The mechanisms of life span extension are diverse and often involve modulating key longevity pathways such as the sirtuins, mTOR, and AMPK. Interventions frequently focus on caloric restriction mimetics, senolytics to clear senescent cells, and optimization of endocrine signaling, notably Growth Hormone and DHEA, which decline with age. By strategically intervening in these core biological processes, the rate of accumulated cellular damage is slowed, thereby delaying the onset of age-related diseases and extending the period of biological function.

Life Span Extension

Meaning

Life Span Extension refers to the scientific and clinical pursuit of increasing the total duration of an organism’s life, typically measured as the time from birth to death. In human health and longevity, this goal is inextricably linked to healthspan, aiming not just for a longer life but for one characterized by minimal disease and sustained vitality. Strategies for life span extension involve targeting the fundamental biological mechanisms of aging, including cellular senescence and genetic pathways. The ultimate ambition is to push the boundaries of human longevity through precise biological and hormonal interventions.