What is the Origin of Life-Span Cognitive Resilience?

This concept integrates findings from cognitive neuroscience, neuroendocrinology, and longevity research, focusing on factors that allow the brain to resist functional decline. It addresses the ability to maintain cognitive performance despite systemic aging. We seek the biological mechanisms underpinning mental longevity.

What is the Mechanism of Life-Span Cognitive Resilience?

Resilience is supported by robust neurotrophic support, particularly BDNF signaling, which is often hormone-sensitive, alongside efficient cerebral vascularity. Stable systemic hormone profiles, especially balanced sex steroids and thyroid function, help maintain neuronal membrane integrity and mitochondrial health, directly preserving synaptic support mechanisms. html

Life-Span Cognitive Resilience ∞ Area

Life-Span Cognitive Resilience

Meaning

Life-Span Cognitive Resilience is the inherent capacity of the central nervous system to buffer against age-related neurological challenges, maintaining high-level executive function and processing speed over many years. It reflects a preserved functional reserve despite cumulative physiological wear. This resilience is an active, maintained state.