The overarching goal of longevity science and proactive medicine, which is defined as increasing the number of years an individual lives in good health, free from significant disease, disability, or decline in physical and cognitive function. This concept prioritizes healthspan—the period of life spent in good health—over mere lifespan. Achieving this extension involves systematic management of the biological processes of aging and disease risk.
Origin
This term is a modern refinement of the public health goal of increasing lifespan, shifting the focus to the quality of those years. It is rooted in gerontology and epidemiology, where metrics like Quality-Adjusted Life Years (QALYs) are used. The emphasis on “extension” is the proactive, interventional aspect of personalized wellness.
Mechanism
Life quality extension is mechanistically achieved by mitigating the accumulation of cellular damage and maintaining the functional reserve of all organ systems. Strategies involve optimizing hormonal signaling, enhancing metabolic efficiency, reducing chronic inflammation, and promoting cellular repair pathways like autophagy. By slowing the rate of systemic wear and tear, the physiological decline associated with chronological aging is decelerated, thereby extending the period of independent, vigorous living.
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