Life Extension Technology refers to the application of advanced scientific and clinical interventions designed to increase both human lifespan and, critically, healthspan—the duration of life spent in good health. This domain encompasses pharmacological agents, bio-identical hormone optimization, genetic and epigenetic modulation, and novel nutritional strategies aimed at mitigating the biological processes of aging. The technology’s core purpose is to maintain physiological function and reduce the incidence of age-related morbidity.
Origin
The concept has philosophical roots in ancient aspirations for immortality, but its modern scientific basis emerged from gerontology and molecular biology research in the late 20th century. The term ‘technology’ reflects the shift from purely theoretical concepts to tangible, clinically applicable interventions based on the science of cellular senescence, telomere dynamics, and mitochondrial decay. It represents the intersection of clinical practice and longevity research.
Mechanism
These technologies operate by targeting the recognized hallmarks of aging at a cellular and systemic level. Interventions may focus on activating longevity pathways such as sirtuins and AMPK, clearing senescent cells through senolytics, or optimizing the endocrine environment to maintain youthful tissue repair and metabolic function. The overall mechanism is a multi-modal effort to enhance DNA repair, improve protein homeostasis, and restore the homeostatic capacity of the entire organism.
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