Interventions, often multimodal, implemented with the explicit goal of slowing the biological processes of aging to extend healthspan and potentially lifespan, frequently targeting endocrine pathways for optimization. These tactics often involve nutritional modulation, targeted supplementation, or lifestyle adjustments aimed at improving cellular repair and reducing senescence. The focus remains on extending the period of robust physiological function.
Origin
This term combines ‘Life Extension’ (the pursuit of increased longevity) with ‘Tactics’ (the methods employed to achieve that goal). It reflects a proactive, interventionist approach to managing the aging phenotype.
Mechanism
Effective tactics often aim to modulate key longevity pathways such as mTOR, AMPK, or sirtuins, which are intrinsically linked to metabolic hormones like insulin and IGF-1. For example, caloric restriction mimetics or optimizing growth hormone/IGF-1 axis signaling through controlled peptide use are common mechanisms employed to enhance cellular maintenance and stress resistance.
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