Life Extension Science Application is the translational process of incorporating validated findings from aging biology research into actionable clinical protocols designed to compress morbidity and extend healthspan. This moves beyond merely treating age-related diseases to actively targeting the underlying mechanisms of biological aging itself. We are applying knowledge to enhance resilience and functional longevity. This approach views aging as a malleable process.
Origin
The application originates from the interdisciplinary field of geroscience, integrating molecular biology, genetics, and endocrinology research findings. The ‘application’ denotes the shift from theoretical discovery to practical patient intervention aimed at delaying age-related functional decline. It reflects a modern understanding that longevity is tied to the sustained health of core physiological systems. This concept underpins proactive health strategies.
Mechanism
The mechanism involves modulating key aging hallmarks, such as epigenetic alterations, mitochondrial dysfunction, and cellular senescence. In the context of hormonal health, this frequently means optimizing anabolic hormones and metabolic regulators to support cellular repair and turnover. Interventions target pathways like mTOR and AMPK to promote cellular maintenance over degradation. The ultimate goal is maintaining youthful physiological performance across the lifespan.
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