Life Extension Practices encompass targeted, proactive health strategies designed to compress morbidity and extend the period of high-quality physiological function, often termed healthspan. These are evidence-informed applications of longevity science aimed at mitigating the rate of biological aging across multiple organ systems. We focus on interventions that directly address the hallmarks of aging.
Origin
The practice is derived from the modern field of biogerontology, which seeks to understand and manipulate the fundamental processes of senescence. It reflects a paradigm shift from reactive disease management to proactive biological maintenance at the molecular level. This approach synthesizes insights from genetics, metabolism, and endocrinology.
Mechanism
The mechanism involves systematically intervening in pathways known to drive aging, such as reducing cellular senescence burden through senolytics or enhancing DNA repair fidelity. Furthermore, these practices frequently incorporate optimizing hormonal milieus, ensuring robust anabolic signaling and minimizing chronic inflammatory states that degrade tissue integrity over time.
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