Life Extension Potential is a theoretical and measurable construct representing the maximal achievable lifespan and healthspan of an individual, based on their current biological state, genetic predispositions, and the application of longevity-focused interventions. This concept is not merely about increasing chronological age but fundamentally focuses on delaying or reversing the biological processes of aging to maximize years of high-quality life. It is the ultimate goal of regenerative and anti-aging medicine.
Origin
The term is rooted in the field of gerontology and biogerontology, combining ‘life extension,’ the effort to slow or reverse aging, with ‘potential,’ signifying the inherent capacity or limit. It is a forward-looking metric that encourages proactive health management based on scientific understanding of the aging process. This framework allows for quantifying the impact of health choices.
Mechanism
Realizing this potential involves interventions that target the hallmarks of aging, including cellular senescence, mitochondrial dysfunction, and genomic instability. By modulating key longevity pathways, such as mTOR, AMPK, and sirtuins, these strategies aim to enhance cellular repair mechanisms and stress resistance. The mechanism is a systematic effort to slow the rate of biological entropy and maintain youthful cellular function for a longer duration.
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