What is the Origin of Life Extension Physiology?

This concept bridges biogerontology with clinical physiology, emphasizing proactive intervention over passive aging. Extension highlights the goal of extending the period of high-quality physiological function. Physiology grounds the approach in measurable, modifiable biological pathways rather than speculative measures. It recognizes that longevity is regulated by conserved molecular mechanisms.

What is the Mechanism of Life Extension Physiology?

Key mechanisms include optimizing nutrient sensing pathways like mTOR and AMPK to favor cellular repair and autophagy over unchecked proliferation. Maintaining youthful pulsatility and amplitude in growth hormone and IGF-1 signaling is often central to this process, supporting tissue regeneration. Furthermore, minimizing accumulated cellular senescence and clearing senescent cells through targeted strategies preserves tissue function and reduces chronic inflammatory signaling.

Life Extension Physiology ∞ Area

Life Extension Physiology

Meaning

Life Extension Physiology refers to the comprehensive set of biological processes and adaptations that promote sustained healthspan and delay the onset of age-related functional decline at the cellular and systemic levels. This involves maintaining telomere integrity, optimizing proteostasis, and preserving the function of critical endocrine axes. We focus on optimizing the body’s inherent machinery to function optimally for a longer duration. This is about biological vigor, not just chronological survival.