Life Extension Engineering is the systematic, evidence-based application of biological, pharmacological, and lifestyle interventions to modulate the fundamental mechanisms of aging, thereby increasing healthspan and potentially lifespan. This advanced field integrates data from genomics, metabolomics, and gerontology to design precise protocols that enhance cellular repair, optimize metabolic function, and bolster systemic resilience. It is a proactive, science-driven pursuit of enhanced human longevity.
Origin
The term combines the aspirational goal of ‘life extension’ with the rigorous, systematic approach of ‘engineering,’ reflecting a shift from theoretical anti-aging to measurable, protocol-driven longevity science. It is rooted in the study of biogerontology and systems biology, where aging is treated as a process that can be strategically optimized. The terminology emphasizes a controlled, predictable outcome.
Mechanism
The engineering process targets key aging hallmarks, including telomere attrition, mitochondrial dysfunction, cellular senescence, and epigenetic alterations. Interventions, which may include senolytics, peptide therapies, and targeted nutritional compounds, are deployed to repair accumulated damage, optimize nutrient sensing pathways like mTOR and AMPK, and restore youthful cellular function. This strategy effectively slows the rate of biological decline.
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