The aggregate spectrum of external and internal stressors—physical, psychological, environmental, and nutritional—that necessitate an adaptive physiological response from the body. These demands tax the homeostatic reserves, requiring continuous allostatic adjustment to maintain equilibrium. High, unmanaged demands lead to systemic fatigue and endocrine strain.
Origin
A broad, integrative term describing the continuous input signals requiring biological effort for survival and function. Within wellness science, it specifically relates to inputs that trigger the HPA axis or significantly alter nutrient partitioning needs.
Mechanism
These demands operate by activating afferent signaling pathways that converge on the central nervous system, initiating sympathetic nervous system outflow and HPA axis activation. Sustained high demands lead to chronic upregulation of catabolic hormones and potential downregulation of reproductive or growth axes. Effective management reduces this chronic activation signal, preserving endocrine function.
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