A comprehensive sub-discipline of endocrinology that studies the progressive and sequential changes in the entire endocrine system, including the synthesis, secretion, and action of hormones, across the entire lifespan of an organism. This field examines the distinct hormonal profiles and regulatory shifts that characterize critical life stages, such as puberty, reproductive maturity, pregnancy, and senescence. Life cycle endocrinology provides a framework for understanding age-related decline and for implementing stage-specific interventions to support health and longevity.
Origin
This conceptual framework originates from classical endocrinology and developmental biology, emphasizing the temporal nature of hormonal control over development and aging. The term highlights the continuum of hormonal influence from in utero development through to the later years of life. It provides a longitudinal perspective on hormonal health that is crucial for clinical practice.
Mechanism
The mechanism involves mapping the changing regulatory dynamics of the major hormonal axes, including the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes, as well as thyroid and growth hormone systems. For example, during aging, the pulsatile release of certain hormones often diminishes in amplitude and frequency, leading to conditions like andropause or menopause. Interventions based on this understanding aim to modulate these declining kinetics to restore a more youthful hormonal environment and support metabolic function.
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