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LHCGR Polymorphisms

Meaning

LHCGR Polymorphisms are common genetic variations, or single nucleotide polymorphisms (SNPs), found within the gene that encodes the Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR). This receptor is fundamentally important for reproductive health, as it mediates the actions of Luteinizing Hormone (LH) and Human Chorionic Gonadotropin (hCG) in both the ovaries and testes. Specific polymorphisms, such as the N312S variant, can alter the receptor’s sensitivity and signaling efficiency, leading to significant inter-individual variability in hormonal response. These genetic differences are key considerations in personalized reproductive medicine.