What is the Origin of LH Stimulation?

The term is derived from the hormone's name, Luteinizing Hormone, which refers to its role in the luteinization of the ovarian follicle, and stimulation, denoting the activation of a biological response. This is a foundational concept within the Hypothalamic-Pituitary-Gonadal (HPG) axis, the master endocrine system governing reproductive physiology.

What is the Mechanism of LH Stimulation?

LH exerts its effect by binding to highly specific G protein-coupled receptors located on the theca cells of the ovary and the Leydig cells of the testis. Receptor binding rapidly activates the adenylate cyclase enzyme system, resulting in a dramatic increase in intracellular cyclic AMP (cAMP). This signaling cascade subsequently drives the necessary enzymatic conversion of cholesterol into the key steroid hormones, progesterone and testosterone, thereby regulating fertility and secondary sex characteristics.

LH Stimulation ∞ Area

LH Stimulation

Meaning

LH stimulation describes the potent biological effect of Luteinizing Hormone, a crucial glycoprotein gonadotropin secreted by the anterior pituitary gland, upon the gonadal tissues. This hormonal signal is the definitive trigger for ovulation in the female reproductive cycle, initiating the transformation of the ovarian follicle into the corpus luteum. In the male, LH stimulation is the primary signal that drives the testicular Leydig cells to synthesize and secrete testosterone.

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How Do Gonadorelin Protocols Maintain Testicular Function?

Gonadorelin protocols maintain testicular function by stimulating the pituitary to release LH and FSH, preserving natural hormone production and fertility.

∞ Androgen-Binding Protein
∞ Testicular Function
∞ Exogenous Testosterone

HRTioJuly 19, 2025

LH Stimulation

Meaning

Origin

Mechanism

How Do Gonadorelin Protocols Maintain Testicular Function?

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