What is the Origin of LH Pulse?

This concept originates from classical neuroendocrinology, where the precise, non-continuous nature of pituitary hormone release was first identified through frequent blood sampling studies in the mid-20th century. The GnRH pulse generator activity is the central driving force, which the LH pulse faithfully mirrors. Understanding this pulsatility is fundamental to diagnosing and treating a wide array of reproductive endocrine disorders, including infertility.

What is the Mechanism of LH Pulse?

The LH pulse is generated when a surge of GnRH binds to its specific receptors on pituitary gonadotroph cells, triggering a rapid exocytosis and release of stored LH. The frequency of these pulses is dynamically modulated by circulating sex steroids and neuropeptides, with faster pulse frequencies often favoring estrogen production and slower frequencies promoting androgen production in the gonads. This dynamic signaling ensures the appropriate and regulated stimulation of the testes or ovaries.

LH Pulse ∞ Area

LH Pulse

Meaning

An LH pulse is a discrete, episodic burst of Luteinizing Hormone secretion from the anterior pituitary gland into the systemic circulation. This pulsatile release pattern is not continuous but occurs in rhythmic, predictable intervals, directly reflecting the upstream pulsatile release of Gonadotropin-releasing hormone (GnRH) from the hypothalamus. The frequency and amplitude of these pulses are crucial regulatory signals for gonadal function, dictating the production of sex steroids in both males and females.