What is the Origin of LH FSH?

The hormones were named based on their primary observed functions in the female reproductive cycle: $text{FSH}$ for stimulating follicular growth and $text{LH}$ for inducing ovulation and the formation of the corpus luteum. The understanding of their pituitary origin and their coordinated pulsatile release under the control of $text{GnRH}$ established them as the master regulators of gonadal function in endocrinology.

What is the Mechanism of LH FSH?

$text{FSH}$ acts by binding to specific receptors on granulosa cells in the ovary and Sertoli cells in the testis, stimulating follicular development and spermatogenesis, respectively. $text{LH}$ binds to receptors on the theca cells in the ovary and Leydig cells in the testis, primarily stimulating the synthesis and secretion of sex steroids, namely estrogen and testosterone. This coordinated, receptor-mediated action drives the cyclical changes of the menstrual cycle and maintains male reproductive function.

LH FSH

Meaning

$text{LH}$ $text{FSH}$ refers to the two critical gonadotropin hormones, Luteinizing Hormone ($text{LH}$) and Follicle-Stimulating Hormone ($text{FSH}$), which are glycoproteins secreted by the anterior pituitary gland. These hormones are central regulators of the reproductive system in both males and females, controlling gamete production and sex steroid hormone synthesis. Their circulating levels and relative ratio are essential diagnostic markers for evaluating fertility and hypothalamic-pituitary-gonadal axis function.

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How Do Gonadorelin Protocols Support Male Fertility When Prior Testosterone Therapy Suppressed It?

Gonadorelin protocols reactivate the HPG axis, stimulating natural testosterone and sperm production suppressed by prior therapy.

∞ HPG Axis
∞ Spermatogenesis
∞ Gonadorelin Protocols

HRTioJuly 20, 2025

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What Laboratory Markers Indicate Pituitary Desensitization from Peptide Therapy?

Pituitary desensitization from peptide therapy is indicated by a blunted hormonal response and altered receptor function, detectable through specific lab markers.

∞ Growth Hormone-Releasing Peptides
∞ Endocrine System
∞ Growth Hormone-Releasing

HRTioJuly 20, 2025