What is the Origin of Leydig Cells?

These cells are named after Franz von Leydig, the German anatomist who first described them in 1850. The term is a direct anatomical and historical designation, linking the cellular structure to its discoverer and their subsequent identified endocrine function.

What is the Mechanism of Leydig Cells?

The activity of Leydig cells is tightly regulated by Luteinizing Hormone (LH), which is secreted by the anterior pituitary gland. Upon binding to its specific receptor on the Leydig cell surface, LH stimulates a cascade of intracellular events that activate the enzymatic pathways of steroidogenesis, converting cholesterol into testosterone. This testosterone then enters the circulation to exert systemic effects or diffuses into the seminiferous tubules to support sperm production.

Leydig Cells ∞ Area

Leydig Cells

Meaning

Specialized interstitial cells located adjacent to the seminiferous tubules in the testes, which serve as the primary site of androgen production in males. These cells are the crucial endocrine component of the testes, responsible for synthesizing and secreting testosterone and other necessary androgens. Their function is essential for male sexual development, spermatogenesis, and maintaining secondary sexual characteristics.

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