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Leydig Cell Oxidative Stress

Meaning

Leydig Cell Oxidative Stress refers to the specific imbalance within the testicular Leydig cells, where the production of reactive oxygen species (ROS) exceeds the cell’s capacity to neutralize them with endogenous antioxidants, leading to cellular damage. Leydig cells are the primary site of testosterone synthesis in males, making them highly susceptible to damage from excessive ROS due to their high metabolic activity. This stress directly impairs the steroidogenic pathway, resulting in reduced testosterone production, a key factor in age-related androgen decline (andropause) and male infertility. Mitigating this stress is a direct clinical target for supporting male hormonal health.