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Leydig Cell Dysfunction

Meaning

Leydig Cell Dysfunction refers to the impaired ability of the testicular Leydig cells to adequately synthesize and secrete androgens, primarily testosterone, in response to appropriate stimulation from Luteinizing Hormone (LH). This condition constitutes primary hypogonadism, characterized by low serum testosterone levels often accompanied by elevated gonadotropins due to a failure of the negative feedback loop. The resulting androgen deficiency can profoundly impact male reproductive health, metabolic function, and overall quality of life.