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Leukotrienes

Meaning

Leukotrienes are a class of potent inflammatory lipid mediators derived from the enzymatic oxidation of arachidonic acid, primarily synthesized by leukocytes and mast cells. These eicosanoids play a critical role in the pathogenesis of allergic and inflammatory responses, notably by increasing vascular permeability and promoting smooth muscle contraction in the airways. In the context of hormonal health, excessive leukotriene activity signifies chronic systemic inflammation that can disrupt endocrine signaling and metabolic homeostasis.