Skip to main content

Leucine Signaling

Meaning

Leucine Signaling refers to the crucial metabolic pathway initiated by the essential branched-chain amino acid leucine, which acts as a nutrient signal to regulate protein synthesis and cellular growth. Leucine is uniquely potent among amino acids in directly activating the mechanistic Target of Rapamycin (mTOR) pathway, a master regulator of anabolism in various tissues, most notably skeletal muscle. This signaling is paramount for maintaining muscle mass, a key determinant of metabolic health and longevity, particularly as hormonal levels decline with age.