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Letrozole Side Effects

Meaning

Letrozole side effects encompass the spectrum of undesirable or unintended pharmacological effects that arise from the therapeutic use of the aromatase inhibitor letrozole, primarily due to its potent estrogen-lowering action. These adverse reactions frequently include symptoms associated with estrogen deficiency, such as musculoskeletal pain, joint stiffness, hot flashes, and bone mineral density loss, particularly in women. In clinical practice, managing these side effects is a critical aspect of ensuring patient adherence to this important hormonal therapy. Less common but serious side effects include elevated lipid profiles and cardiovascular concerns.