What is the Origin of Leptin Signaling Integrity?

The term originated following the discovery of leptin and its receptor, leading to the understanding of the lipostatic theory of energy balance. "Integrity" emphasizes the functional wholeness of the signaling cascade, which can be compromised by a condition known as leptin resistance. This resistance represents a failure of the central nervous system to respond appropriately to high circulating leptin levels.

What is the Mechanism of Leptin Signaling Integrity?

Leptin is released from adipose tissue and travels to the arcuate nucleus of the hypothalamus, where it binds to its specific receptor (LepRb). This binding activates the JAK-STAT signaling pathway, which promotes the expression of anorexigenic neuropeptides like POMC while inhibiting the expression of orexigenic neuropeptides like NPY. When integrity is lost, the signaling cascade is blunted, and the brain incorrectly perceives a state of starvation, despite high body fat.

Leptin Signaling Integrity ∞ Area

Leptin Signaling Integrity

Meaning

Leptin Signaling Integrity refers to the unimpaired functionality of the biological pathway through which the adipocyte-derived hormone leptin transmits its satiety and energy-status signal to the hypothalamus and other target tissues. Leptin acts as the body’s primary long-term indicator of energy stores, suppressing appetite and increasing energy expenditure. Maintaining integrity means that the brain accurately perceives the leptin signal, which is crucial for preventing weight gain and metabolic dysregulation.