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Leptin Signaling Hypothalamus

Meaning

Leptin Signaling Hypothalamus refers to the critical pathway where the adipocyte-derived hormone leptin transmits information about long-term energy stores (fat mass) to the central nervous system, specifically the hypothalamus, to regulate appetite, energy expenditure, and reproductive function. This signaling is paramount for metabolic and endocrine homeostasis, as the hypothalamus interprets these signals to adjust its neuroendocrine output. Dysfunctional leptin signaling, often seen in states of obesity or severe energy restriction, can lead to significant systemic dysregulation.