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Leptin Signaling Disruption

Meaning

Leptin Signaling Disruption describes a state of functional resistance where the central nervous system and peripheral tissues fail to respond appropriately to the satiety hormone leptin, despite the presence of high circulating levels. This acquired resistance is a defining hallmark of obesity and significant metabolic dysfunction, inevitably leading to a persistent, unmanaged perception of hunger and impaired regulation of energy expenditure. The disruption fundamentally compromises the body’s intrinsic ability to maintain long-term energy homeostasis and a healthy body weight set point.