What is the Origin of Leptin Satiety Timing?

This concept is rooted in the discovery of leptin, the "satiety hormone," and its subsequent integration into the framework of chronobiology. Timing refers to the critical synchronization of leptin's secretion and receptor sensitivity with the body's feeding and fasting cycles. Satiety is the feeling of fullness.

What is the Mechanism of Leptin Satiety Timing?

Leptin levels generally correlate with body fat stores and are released in a pulsatile, circadian manner, peaking during the nocturnal rest phase to prevent hunger while sleeping. Consistent, early-day feeding and a prolonged overnight fast help maintain the sensitivity of leptin receptors in the hypothalamus. Late-night eating or sleep deprivation can disrupt this rhythm, leading to lower nocturnal leptin signaling or desensitization, which impairs appetite control and metabolic efficiency the following day.

Leptin Satiety Timing ∞ Area

Leptin Satiety Timing

Meaning

The chronobiological principle of ensuring the proper, rhythmic release and central signaling of the adipose-derived hormone leptin to effectively communicate long-term energy sufficiency and promote satiety at the appropriate time. Disrupted timing can lead to leptin resistance, where the brain fails to register the satiety signal, contributing to overeating and weight gain. Optimal timing is critical for maintaining energy homeostasis.