What is the Origin of Leptin Resistance Stress?

This term is a clinical synthesis, combining the well-documented phenomenon of leptin resistance in obesity with the known impact of stress on neuroendocrine function. It highlights the pathological convergence of two major modern health challenges: chronic stress and metabolic dysfunction.

What is the Mechanism of Leptin Resistance Stress?

Chronic stress elevates circulating glucocorticoids like cortisol, which have been shown to interfere with leptin transport across the blood-brain barrier or to directly inhibit leptin signaling pathways in the hypothalamus. Furthermore, stress-induced inflammation releases cytokines that can impair the function of the leptin receptor. This combined neuroendocrine disruption effectively blocks the crucial satiety signal, overriding the body's normal homeostatic control of energy balance.

Leptin Resistance Stress ∞ Area

Leptin Resistance Stress

Meaning

Leptin resistance stress is a complex physiological state where chronic psychological or physiological stress contributes to the failure of the central nervous system to appropriately respond to the satiety hormone leptin. Leptin, normally secreted by adipose tissue to signal energy sufficiency, becomes ineffective at the hypothalamic level. This resistance leads to a perceived state of starvation in the brain, driving increased appetite, reduced energy expenditure, and a persistent push toward weight gain, compounded by the metabolic effects of chronic stress.