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Leptin Resistance Signaling

Meaning

Leptin Resistance Signaling is a pathological state where the hypothalamus and other crucial target tissues exhibit a significantly diminished or entirely absent response to the potent appetite-suppressing and long-term energy-regulating effects of the hormone leptin. This fundamental resistance severely disrupts the homeostatic negative feedback loop designed to maintain energy balance, frequently resulting in persistent feelings of hunger, an increase in energy storage, and subsequent weight gain. It represents a core breakdown in the sophisticated communication system that governs metabolic stability.